UPC Code: Conenzyme Q-10 - 100 Softgels Bottle: 6 66720 00325

Medicinal Ingredients (per Softgel): Coenzyme Q10 (Ubiquinone-10) (Synthetic USP)....................100 mg Vitamin E (as d-alpha Tocopherol with Mixed Tocopherols) 10mg/1000IU

Non Medicinal Ingredients: Capsule (Bovine Gelatin, Purified water).
Recommended Use or Purpose:

• An antioxidant for the maintenance of good health
• Helps to maintain and/or support cardiovascular health.
• Helps to reduce the frequency of migraine headaches and associated nausea and vomiting when taken as a prophylactic.

Route of administration: Oral.
Dosage - Adults: Take one (1) softgel 1 to 3 times a day with water or juice before meals.
Duration of use: Use for a minimum of 3 months to start experiencing the beneficial effects.
Cautions and Warnings:Consult a health care practitioner prior to use if you are pregnant or breastfeeding, if you are taking blood pressure medication, or if you are taking blood thinners. Consult a health care practitioner if migraine frequency increases, and associated nausea and vomiting persist or worsen.
Caution: Keep Out Of Reach Of Children. Store in a cool dry place. Security seal on cap for your protection. Do not use if seal is broken.
Contains No: sucrose, no lactose, no preservatives, no yeast, no gluten, no salt, no GMO.

Coenzyme Q10® SUGGESTED
CONSUMPTION TABLE GUIDELINE*

TOP BENEFITS of
MVP's Coenzyme Q10®*

1. An antioxidant for the maintenance of good health.
2. Helps to maintain and/or support cardiovascular health.
3. Helps to reduce the frequency of migraine headaches and associated nausea and vomiting when taken as a prophylactic.

Scientific Insight
Coenzyme Q10, also known as ubiquinone, ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10, CoQ, Q10, or Q, is  a compound found naturally in the energy-producing center of the cell known as the mitochondria. CoQ10 is involved in making an important molecule known as adenosine triphosphate (ATP). ATP serves as the cell's major energy source and drives a number of biological processes, including muscle contraction and the production of protein.

CoQ10 And Athletic Performane

There plenty of studies showing that CoQ10 can significantly improve athletic performance (1,2) and less that it does a little bit better then placebo (3). These research were conducted on cross-country skiers and sedentary men in the gym, here CoQ10 showed performance-enhancing effects, when on more trained men, the effects were less (3).

CoQ10 Is A  Beneficial Antioxidant

CoQ10 is supportive to reduce oxidative damage to tissues as well as significantly inhibit the oxidation of LDL cholesterol (4, 5). This is a great aid for diseases. In keeping with the free radical theory of aging, these antioxidant properties of CoQ10 have clear implications in the slowing of aging.

Summary Of Other Health Benefits

References:
1.Gökbel H et al. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond Res. 2010 Jan; 24(1):97-102.
2. Ylikoski T et al. The effect of coenzyme Q10 on the exercise performance of cross-country skiers. Mol Aspects Med. 1997; 18 Suppl: S283-90.
3.Malm C et al. Effects of ubiquinone-10 supplementation and high intensity training on physical performance in humans. Acta Physiol Scand. 1997 Nov; 161(3):379-84.
4.Bowry VW et al. Prevention of tocopherol-mediated peroxidation in ubiquinol-10-free human low density lipoprotein. J Biol Chem. 1995 Mar 17; 270(11):5756-63.
5.Ingold KU et. Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein. Proc Natl Acad Sci U S A. 1993 Jan 1; 90(1):45-9.
6.Hoppe U et al. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999; 9(2-4):371-8.
7.Rosenfeldt F et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. Journal of Thoracic Cardiovascular Surgery 2005; 129(1):25-32.
8. Rosenfeldt FL et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. Journal of Human Hypertension 2007; 21(4):297-306.
9. Baggio E et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Molecular Aspects of Medicine 1994; 15 (Supplement 1):S287-S294.
10.Hershey AD et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache 2007; 47(1):73-80.
11.Sandor PS et. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology 2005; 64(4):713-715.

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Why is Coenzyme Q10 from MVP Biotech® different from others?

There are three key reasons to choose MVP Biotech® CoQ10:

What is CoQ10?

It is a fat-soluble vitamin-like substance present in every cell of the body and serves as a coenzyme for several of the key enzymatic steps in the production of energy within the cell.

Which Foods Contain Coenzyme Q10?

There are plenty of the food sources. The top products are beef (heart and liver), pork (heart and liver), fish (sardine and red flesh), oils (soybean), nuts (peanuts), vegetables (parsley and broccoli) and fruit (avocado) (1).

Why are you using synthetic CoQ10 instead of natural one?

We are doing a fair business. There is no scientific proof showing that our CoQ10 is somehow worse then natural one. We are delivering the best quality CoQ10 to our users.

Is a powder form of Coenzyme Q10 better than solubilized form which is used in Coenzyme Q10 from MVP Biotech®?

The solubilized form is much better absorbed than powder form. On animal model showed solubilized form bioavailability constituted 264% of that for the powder form (2). Moreover, we are using ubiquinol form, which was shown 40% more effective than ubiquinone form (3).

Why are you using Vitamin E along with Coenzyme Q10?

Combination of CoQ10 and vitamin E caused a prolonged improvement in cardiac and skeletal muscle bioenergetics clearly demonstrating its biochemical efficacy (4).

In the description, you haven’t highlighted a link from oxidative stress to performance, is CoQ10 helpful for removing this harmful metabolic state in this case?

This state is not 100% harmful, according to the recent review the role of oxidative stress on muscle homeostasis is quite complex (5). There is no data yet showing how CoQ10 is effective in removing oxidative stress in human muscles, except a heart one. However, as CoQ10 is a great antioxidant (6-8) and since our professional athletes reports some helpful information and there are some animal studies (9, 10), we can say that it is more likely that CoQ10 is helpful for supporting normal oxygen balance in your muscles (*).

Why Coenzyme Q10 is started to be so popular?

One reason is increased awareness that some medicines and supplements used to lower LDL and cholesterol deplete CoQ10 levels in the blood, and possibly the tissues (11).

How long will it take for me to see results with Coenzyme Q10 from MVP Biotech®?

You should start to see results within 1 to 3 weeks. This is the average amount of time reported by our users. But remember, results may vary.

I am a 40 years old male athlete, should I Take Coenzyme Q10?

Coenzyme Q10 levels may decline with aging. Despite of a lack studies on human model, combine animal studies and human tissue study showied the decline with age (ex. in heart muscle wall by 72%) (12).

I am a beginner female athlete. Can Coenzyme Q10 help me with weight loss?

There are opposite opinions for weight loss properties of Coenzyme Q10, some studies show that it is helpful (13), some that it is not effective (14). However, our users mostly report positive effects of Coenzyme Q10 with different types of weight loss diets and supplementation (*).

How should I take Coenzyme Q10?

We recommend taking one (1) softgel 1 to 3 times a day with water or juice before meals.

Is Coenzyme Q10 safe?

Use Coenzyme Q10 only as directed. Do not use: If you have any medical conditions or are taking any medications. Please consult your physician prior to consumption. For additional info please see Contraindications and Warnings.

Where can I buy Coenzyme Q10?
Please visit our retailers’ page http://mvpbiotech.com/order.html.

References:
1). Pravst I et al. Coenzyme Q10 contents in foods and fortification strategies. Crit Rev Food Sci Nutr. 2010 Apr;50(4):269-80.
2). Kalenikova et al. Pharmacokinetics of coenzyme q10. Bull Exp Biol Med. 2008 Sep; 146(3):313-6.
3). Yan J et al. Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. Exp Gerontol. 2006 Feb; 41(2):130-40.
4). Hart PE et al. Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up. Arch Neurol. 2005 Apr; 62(4):621-6.
5). Musarò A. et al. Oxidative stress and muscle homeostasis. Current Opinion in Clinical Nutrition & Metabolic Care: May 2010 - Volume 13 - Issue 3 - p 236–242. 
6). Kalpravidh RW et al.  Effect of coenzyme Q10 as an antioxidant in β-thalassemia/Hb E patients.  BioFactors 2005; 25(1-4):225-234.
7). Rosenfeldt F et al.  Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue.  Journal of Thoracic Cardiovascular Surgery 2005; 129(1):25-32.
8). Crane FL.  Biochemical functions of coenzyme Q10.  Journal of the American College of Nutrition 2001; 20(6):591-598.
9). Ochoa JJ et al. Effect of lifelong coenzyme Q10 supplementation on age-related oxidative stress and mitochondrial function in liver and skeletal muscle of rats fed on a polyunsaturated fatty acid (PUFA)-rich diet. J Gerontol A Biol Sci Med Sci. 2007 Nov; 62(11):1211-8.
10). Sohal RS, Forster MJ. Coenzyme Q, oxidative stress and aging. Mitochondrion. 2007 Jun; 7 Suppl: S103-11.
11). Nawarskas JJ. HMG-CoA reductase inhibitors and coenzyme Q10. Cardiol Rev. 2005 Mar-Apr; 13(2):76-9.
12). Rosenfeldt FL et al. Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue. Biofactors. 1999; 9(2-4):291-9.
13). van Gaal L et al. Exploratory study of coenzyme Q10 in obesity. In: Folkers K,Yamamura Y, eds: Biomedical and Clinical Aspects of Coenzyme Q, Vol 4. Elsevier Science Publ, Amsterdam, 1984. Pp369-73.
14) Lockwood K et al. Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med. 1994; 15 Suppl: s231-40.